M.Wang Lab
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M. Wang, R. Chaudhuri, W.W.S. Ong, H.O. Sintim, “c-di-GMP induces COX-2 expression in macrophages in a STING-independent manner” ACS Chemical Biology, 2021, 16, 1663.
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N. Dayal, M. Wang, and H. O. Sintim. “HSD1787, a Tetrahydro-3H-Pyrazolo[4,3-f]Quinoline Compound Synthesized via Povarov Reaction, Potently Inhibits Proliferation of Cancer Cell Lines at Nanomolar Concentrations” ACS Omega, 2020, 5, 23799
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U. K. Aryal, V. H. Kenneth, I. Onyedibe, T. J. P. Sobreira, M. A. Sooreshjani, M. Wang, U. K. Gürsoy, H. O. Sintim. “Global Proteomic Analyses of STING‐Positive and‐Negative Macrophages Reveal STING and Non‐STING Differentially Regulated Cellular and Molecular Pathways” Proteomics Clin. Appl., 2020, 14, 1900109.
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N. Dayal, C. Opoku-Temeng, H. Mohammad, N. S. Abutaleb, D. Hernandez, K. I. Onyedibe, M. Wang, M. Zeller, M. N. Seleem, H. O. Sintim. “Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov–Doebner Reactions” ACS Infect. Dis., 2019, 5, 1820.
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M. Wang, N. Naganna, H. O. Sintim. “Identification of nicotinamide aminonaphthyridine compounds as potent RET kinase inhibitors and antitumor activities against RET rearranged lung adenocarcinoma” Bioorg. Chem., 2019, 90, 103052.
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M. Wang, H. O. Sintim. “Discriminating cyclic from linear nucleotides − CRISPR/Cas- related cyclic hexaadenosine monophosphate as a case study” Anal. Biochem., 2019, 567, 21.
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N. Naganna, C. Opoku-Temeng, E. Y. Choi, E. Larocque, E. T. Chang, B. A. Carter-Cooper, M. Wang, S. E. Torregrosa-Allen, B. D. Elzey, R. G. Lapidus, H. O. Sintim. “Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice” EBioMedicine, 2019, 40, 231.
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C. G. Mikek, M. Wang, M. Sooreshjani, H. O. Sintim. “Interrupting cyclic dinucleotide-cGAS-STING axis and other inflammatory pathways with small molecules” MedChemComm, 2019, 10, 1999.
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K. I. Onyedibe, M. Wang, H. O. Sintim. “ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1” Molecules, 2019, 24, 4192.
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M. Wang, M. Sooreshjani, C. Mikek, C. Opoku-Temeng, H. O. Sintim. “Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels” Future Med. Chem., 2018, 10, 1301.
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M. Wang, W. Wang, C. Liu, J. Liu, T.-S. Kang, C.-H. Leung, D.-L. Ma. “A luminescent switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters” Mater. Chem. Front., 2017, 1, 128.
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M. Wang, Z. Mao, T.-S. Kang, C.-Y. Wong, J.-L. Mergny, C.-H. Leung, D.-L. Ma. “Conjugating a groove-binding motif to Ir(III) complex for the enhancement of G-quadruplex probe behavior” Chem. Sci., 2016, 7, 2516.
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Z. Mao, M. Wang, J. Liu, L.-J. Liu, S. M.-Y. Lee, C.-H. Leung, D.-L. Ma. “A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish” Chem. Commun., 2016, 52, 4450.
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D.-L. Ma, M. Wang, Z. Mao, C. Yang, C.-T. Ng, C.-H. Leung. “Rhodium complexes as therapeutic agents” Dalton Trans., 2016, 45, 2762.
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W. Wang, Z. Mao, M. Wang, L.-J. Liu, D.W.J. Kwong, C.-H. Leung, D.-L. Ma. “A long lifetime luminescent iridium(III) complex chemosensor for selective switch-on detection of Al3+ ions” Chem. Commun.,2016, 52, 3611.
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T.-S. Kang, Z. Mao, C.-T. Ng, M. Wang, W. Wang, C. Wang, Simon M.-Y. Lee, Y. Wang, C.-H. Leung, D.-L. Ma. “Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α” J. Med. Chem., 2016, 59, 4026.
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L. Lu, W. Wang, M. Wang, T.-S. Kang, J.-J. Lu, Q.-B. Han, C.-H. Leung, D.-L. Ma. “A luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of lysozyme” J. Mater. Chem. B, 2016, 4, 2407.
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L. Lu, M. Wang, Z. Mao, T.-S. Kang, X.-P. Chen, J.-J. Lu, C.-H. Leung, D.-L. Ma. “ A noveldinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α” Sci. Rep., 2016, 6, 22458.
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D.-L. Ma, M. Wang, C. Liu, X. Miao, T.-S. Kang, C.-H. Leung. “Metal complexes for the detection of disease-related protein biomarkers” Coord. Chem. Rev., 2016, 324, 90.
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M. Wang, W. Wang, T.-S. Kang, C.-H. Leung, D.-L. Ma. “Development of an iridium(III) complex as a G-quadruplex probe and its application for the G-quadruplex-based luminescent detection of picomolar insulin” Anal. Chem., 2015, 88, 981.
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M. Wang, B. He, C.-H. Leung, J.-L. Mergny, D.-L. Ma. “Label-free luminescent detection of LMP1 gene deletion using an intermolecular G-quadruplex-based switch-on probe” Biosens. Bioelectron., 2015, 70, 338.
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D.-L. Ma, M. Wang, B. He, C. Yang, W. Wang, C.-H. Leung. “A luminescent cocaine detection platform using a split G-quadruplex-selective iridium(III) complex and a three-way DNA junction architecture” ACS Appl. Mater. Interfaces, 2015, 7, 19060.
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L. Lu, M. Wang, L.-J. Liu, C.-H. Leung, D.-L. Ma. “A label-free luminescent switch-on probe for ochratoxin A detection using a G-quadruplex-selective iridium(III) complex” ACS Appl. Mater. Interfaces, 2015, 7, 8313.
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L. Lu, M. Wang, L.-J. Liu, C.-Y. Wong, C.-H. Leung, D.-L. Ma. “A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe” Chem. Commun., 2015, 51, 9953.
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D.-L. Ma, M. Wang, S. Lin, Q.-B. Han, C.-H. Leung. “Recent development of G-quadruplex probes for cellular imaging” Curr. Top. Med. Chem., 2015, 15, 1957.
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D.-L. Ma, Z. Zhang, M. Wang, L. Lu, H.-J. Zhong, C.-H. Leung. “Recent developments in G-quadruplex probes” Cell Chemical Biology., 2015, 22, 812.
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D.-L. Ma, S. Lin, L. Lu, M. Wang, C. Hu, L.-J. Liu, K. Ren, C.-H. Leung. “G-quadruplex-based logic gates for HgII and AgI ions employing a luminescent iridium(III) complex and extension of metal-mediated base pairs by polymerase” J. Mater. Chem. B, 2015, 3, 4780.
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Z. Zhong, L.-J. Liu, Z.-Q. Dong, L. Lu, M. Wang, C.-H. Leung, D.-L. Ma, Y.-T. Wang. “Structure-based discovery of an immunomodulatory inhibitor of TLR1-TLR2 heterodimerization from a natural product-like database” Chem. Commun., 2015, 51, 11178.
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L. Lu, H.-J. Zhong, M. Wang, S.-L. Ho, H.-W. Li, C.-H. Leung, D.-L. Ma. “Inhibition of beta-amyloid fibrillation by luminescent iridium(III) complex probes” Sci. Rep., 2015, 5, 14619.
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L. Lu, L.-J. Liu, W. Chao, H.-J. Zhong, M. Wang, X.-P. Chen, J.-J. Lu, R. Li, D.-L. Ma, C.-H. Leung. “Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity” Sci Rep, 2015, 5, 14544.
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K.-H.Leung, L.-J. Liu, S. Lin, L. Lu, H.-J. Zhong, D. Susanti, W. Rao, M. Wang, W. I. Che, D. S.-H. Chan, C.-H. Leung, P. W. H. Chan, D.-L. Ma. “Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening” Methods, 2015, 71, 38.
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D.-L. Ma, M. Wang, W. Wang, L. Lu, D. H.-M. Wang, C.-H. Leung. “A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe” Sci. Lett. J., 2015, 4, 180.
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M. Wang, K.-H. Leung, S. Lin, D. S.-H. Chan, C.-H. Leung, D.-L. Ma. “A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C-Ag+-C DNA” J. Mater. Chem. B, 2014, 2, 6467.
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M. Wang, K.-H. Leung, S. Lin, D. S.-H. Chan, D.W.J. Kwong, C.-H. Leung, D.-L. Ma. “A colorimetric chemosensor for Cu2+ ion detection based on an iridium(III) complex” Sci. Rep., 2014, 4, 6794.
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H.-J. Zhong, L.-J. Liu, C.-M. Chong, L. Lu, Z. Ai, M. Wang, D. S.-H. Chan, P. W.H. Chan, S. M.-Y Lee, D.-L. Ma, C.-H. Leung. “Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo.” Plos One, 2014, 4, e92905.
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H.-Z. He, M. Wang, D. S.-H. Chan, C.-H. Leung, J.-W. Qiu, D.-L. Ma. “A label-free G-quadruplex-based luminescent switch-on assay for the selective detection of histidine” Methods, 2013, 64, 205.
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H.-Z. He, M. Wang, D. S.-H. Chan, C.-H. Leung, X. Lin, J.-M. Lin, D.-L. Ma. “A parallel G-quadruplex-selective luminescent probe for the detection of nanomolar calcium(II) ion” Methods, 2013, 64, 212.
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K.-H. Leung, L. Lu, M. Wang, T.-Y. Mak, D. S.-H. Chan, F.-K. Tang, C.-H. Leung, H.-Y. Kwan, Z. Yu, D.-L. Ma. “A label-free luminescent switch-on assay for ATP using a G-quadruplex-selective iridium(III) complex” PLos ONE, 2013, 10, e77921.
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D. S.-H. Chan, W.-C. Fu, M. Wang, C.-H. Leung, D.-L. Ma. “A highly selective and non-reaction based chemosensor for the detection of Hg2+ ions using a luminescent iridium(III) complex” PLoS ONE, 2013, 8, e60114.
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H.-Z. He, W.-I. Chan, T.-Y. Mak, L.-J. Liu, M. Wang, D. S.-H. Chan, D.-L. Ma, C.-H. Leung. “Detection of 3’ → 5’ exonuclease activity using a metal-based luminescent switch-on probe” Methods, 2013, 64, 218.
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C.-H Leung, H.-Z He, L.-J. Liu, M. Wang, D. S.-H. Chan, D.-L. Ma. “Metal complexes as inhibitors of transcription factor activity” Coord. Chem. Rev., 2013, 257, 3139.